Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino …

By recruiting several proteins that bind actin filaments, the cytoplasmic tails mediate the integrin-cytoskeletal connection, which is essential for most, if not all, integrin mediated functions (see …

Jan 2, 2023 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational …

Nov 30, 2023 · The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. Integrins function as adhesion receptors for extracellular …

Sep 28, 2022 · Dr. Hynes coined the term “integrin” for these wonderfully complicated molecules that “integrate” the extracellular matrix with the intracellular environment (the cytoskeleton, in …

In this review, I will first give a brief overview of the integrin family to set the context and then review the recent structural data and experiments arising from them, which give insight into …

May 1, 2020 · We focus on more recent advances in conformational regulation and thermodynamics of integrin activation, and on a subset of the key protein-protein interactions …

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a metazoan existence. All members of the integrin family adopt a shape that resembles a large “head” on …

Oct 7, 2020 · This review presents current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.

Except for the role of external and internal mechanical forces and integrin conformational changes in affinity modulation, integrin has also been shown to form clusters or accumulate at one part …