Nature

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form ...
ascopubs.org

Phase I evaluation of the PI3 kinase (PI3K) inhibitor taselisib (GDC-0032) in multiple locally advanced or metastatic PIK3CA mutant solid tumor types.

Biomarker-driven access to vemurafenib in BRAF-positive cancers: Second study of the French National AcSé Program. This is an ASCO Meeting Abstract from the 2016 ASCO Annual Meeting I. This abstract ...
ascopubs.org

A phase Ib study to evaluate the PI3-kinase inhibitor GDC-0941 with paclitaxel (P) and carboplatin (C), with and without bevacizumab (BEV), in patients with advanced non-small ...

Oral PI3 kinase inhibitor BKM120 monotherapy in patients (pts) with advanced solid tumors: An update on safety and efficacy. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This ...
Nature

The emerging role of the PI3-K-Akt pathway in prostate cancer progression

Prostate cancer remains the second leading cause of cancer mortality among American males. The predominant reason for such high and persistent mortality is the lack of curative therapies for ...