Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids, traditionally recognised for their role in lipid digestion, have emerged as key modulators of metabolic homeostasis. Recent research has explored how these endogenous molecules can ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

There are trillions of microbes in the gastrointestinal tract, and we are starting to learn more about the exact mechanisms that link those microbes and the substances they generate to changes in ...

A simple stool test could soon revolutionize chronic diarrhoea diagnosis in India. Researchers found measuring bile acids in ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Researchers headed by teams at the Salk Institute and at the University of California, San Diego (UCSD), have discovered, in mice, how high-fat diets (HFDs) can change gut bacteria and alter digestive ...

Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking ...

Primary bile acids are produced by the liver and released into the gut, where diverse groups of bacteria work together to modify their chemical structures. Researchers suspected these gut microbial ...

DEAR DR. ROACH: I’m a 67-year-old female in pretty good health. The only medications I take are for my thyroid, arthritis and hormone replacement. Early last year, I was sick with a cold/flu for a ...